 | Kris J. Kontis, Senior Scientist, Hycor Biomedical Inc.,
Garden Grove, CA |
| Michael K. Pugsley, Director of
Pharmacology & Toxicology, XOMA Corporation, Berkeley, CA |
| Ray D. Smith, Research Scientist at
Digital Gene Technologies, La Jolla, CA |
| Marianne R. Smith, Consulting Scientist
at Ingenuity Systems, Alviso, CA |
| Ted M. Shih, postdoctoral fellow with Dr. Steve Goldstein,
Yale University |
| Dave E. Patton, Research Associate with
Dr. David Krantz, Department of Psychiatry, UCLA |
Recent Publications:
Spampanato, J., A. Escayg, M.H.
Meisler and A.L. Goldin. 2003. The generalized epilepsy with febrile seizures
plus type 2 mutation W1204R alters voltage-dependent gating of Nav1.1
sodium channels. Neurosci. 116:37-48.
Goldin, A.L. 2002. Evolution of
voltage-gated Na+ channels. J. Exp. Biol. 205:575-584.
Spampanato, J., A.
Escayg, M.H. Meisler and A.L. Goldin. 2001. Functional effects of two
voltage-gated sodium channel mutations that cause generalized epilepsy with
febrile seizures plus type 2. J. Neurosci. 21:7481-7490.
Goldin, A.L. 2001. Resurgence of sodium channel research.
Annu. Rev. Physiol.
63:871-894.
Goldin, A.L., R.L. Barchi, J.H.
Caldwell, F. Hofmann, J.R. Howe, J.C. Hunter, R.G. Kallen, G. Mandel, M.H.
Meisler, Y. Berwald-Netter, M. Noda, M.M. Tamkun, S.G. Waxman, J.N. Wood and
W.A. Catterall. 2000. Nomenclature of voltage-gated sodium channels. Neuron
28:365-368.
Kearney, J.A., N.W. Plummer,
M.R. Smith, J. Kapur, T.R. Cummins, S.G. Waxman,
A.L. Goldin and M.H. Meisler. 2000. A gain-of-function mutation in the sodium
channel gene Scn2a results in seizures and behavioral abnormalities. Neurosci.
102:307-317.
Smith, R.D. and A.L. Goldin. 2000. Potentiation of rat brain
sodium currents by PKA in Xenopus oocytes involves the
I-II linker. Am. J. Physiol. Cell Physiol. 278:C638-C645.
Goldin, A.L.. 1999. Diversity of mammalian voltage-gated
sodium channels, in Molecular and Functional Diversity of Ion
Channels and Receptors. Annals of the New York Academy of
Sciences, Eds. Rudy, B. and Seeburg, P., 868:38-50.
Smith, M.R. and A.L. Goldin. 1999. A mutation that causes ataxia shifts
the voltage-dependence of the scn8a sodium channel. NeuroReport
10:3027-3031.
Pugsley, M.K. and A.L. Goldin. 1999. Molecular Analysis of the
Na+ channel blocking actions of the novel class I
antiarrhythmic agent RSD 921. Br. J. Pharmacol. 127:9-18.
Smith, R.D.
and A.L. Goldin. 1998. Functional analysis of the rat I sodium
channel in Xenopus oocytes. J. Neurosci.18:811-820.
Pugsley, M.K .and A.L. Goldin. 1998. Effects of bisaramil, a
novel class I antiarrhythmic agent, on heart, skeletal muscle and
brain Na+ channels. Eur. J. Pharmacol. 342:93-104.
Smith, M.R,
R.D. Smith, N.W. Plummer, M.H. Meisler and A.L. Goldin. 1998.
Functional analysis of the mouse Scn8a sodium channel. J.
Neurosci.18:6093-6102.
Shih, T.M. R.D Smith, L. Toro and A.L. Goldin. 1998.
High-level expression and detection of ion channels in Xenopus
oocytes. Methods in Enzymology, ed. Conn, P.M., 293:529-556.
Shih, T.M. and A.L.
Goldin. 1997. Topology of the Shaker potassium channel
probed with hydrophilic epitope insertions. J. Cell Biol.
136:1037-1045.
Cantrell,
A.R., R.D. Smith, A.L. Goldin, T. Scheuer and W.A. Catterall.
1997. Dopaminergic modulation of sodium current in hippocampal
neurons via cAMP-dependent phosphorylation of specific site(s) in
the sodium channel a subunit. J.
Neurosci. 17:7330-7338.
Smith, R.D.
and A.L. Goldin. 1997. Phosphorylation at a single site in the
rat brain sodium channel is necessary and sufficient for current
reduction by PKA. J. Neurosci. 17:6086-6093.
Smith, M.R. and A.L. Goldin. 1997. Interaction between the
sodium channel inactivation linker and domain III S4-S5. Biophys.
J. 73:1885-1895.
Kontis, K.J. and
A.L. Goldin. 1997. Sodium channel activation gating is altered by
substitution of voltage sensor positive charges. J. Gen. Physiol.
110:391-401.
Kontis, K.J. and
A.L. Goldin. 1997. Sodium channel inactivation is altered by
substitution of voltage sensor positive charges. J. Gen. Physiol.
110:403-413.
Kohrman, D.C., M.R. Smith, A.L. Goldin, J. Harris and
M.H. Meisler. 1996. A
missense mutation in the sodium channel Scn8a is responsible for
cerebellar ataxia in the mouse mutant jolting. J.
Neurosci. 16:5993-5999.
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