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Current Research Interests:

bulletDiseases caused by sodium channel mutations
bulletRole of different channel isoforms in the nervous and cardiovascular systems
bulletInteractions between the sodium channel and antiarrhythmic and local anesthetic drugs
bulletMolecular basis of sodium channel inactivation
bulletThe role of the S4 regions is sodium channel activation
bulletModulation of sodium channels by phosphorylation

Current Lab Members:

bulletAl Goldin
bulletAnnie Lee
bulletJay Spampanato
bulletWei Zhou
bulletA.J. Barela
bulletHai Nguyen
bulletBrian Tanaka

Previous Lab Members:

bulletKris J. Kontis, Senior Scientist, Hycor Biomedical Inc., Garden Grove, CA
bulletMichael K. Pugsley, Director of Pharmacology & Toxicology, XOMA Corporation, Berkeley, CA
bulletRay D. Smith, Research Scientist at Digital Gene Technologies, La Jolla, CA
bulletMarianne R. Smith, Consulting Scientist at Ingenuity Systems, Alviso, CA
bulletTed M. Shih, postdoctoral fellow with Dr. Steve Goldstein, Yale University
bulletDave E. Patton, Research Associate with Dr. David Krantz, Department of Psychiatry, UCLA

Recent Publications:

Spampanato, J., A. Escayg, M.H. Meisler and A.L. Goldin. 2003. The generalized epilepsy with febrile seizures plus type 2 mutation W1204R alters voltage-dependent gating of Nav1.1 sodium channels. Neurosci. 116:37-48.

Goldin, A.L. 2002. Evolution of voltage-gated Na+ channels. J. Exp. Biol. 205:575-584.

Spampanato, J., A. Escayg, M.H. Meisler and A.L. Goldin. 2001. Functional effects of two voltage-gated sodium channel mutations that cause generalized epilepsy with febrile seizures plus type 2. J. Neurosci. 21:7481-7490.

Goldin, A.L. 2001. Resurgence of sodium channel research. Annu. Rev. Physiol. 63:871-894.

Goldin, A.L., R.L. Barchi, J.H. Caldwell, F. Hofmann, J.R. Howe, J.C. Hunter, R.G. Kallen, G. Mandel, M.H. Meisler, Y. Berwald-Netter, M. Noda, M.M. Tamkun, S.G. Waxman, J.N. Wood and W.A. Catterall. 2000. Nomenclature of voltage-gated sodium channels. Neuron 28:365-368.

Kearney, J.A., N.W. Plummer, M.R. Smith, J. Kapur, T.R. Cummins, S.G. Waxman, A.L. Goldin and M.H. Meisler. 2000. A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities. Neurosci. 102:307-317.

Smith, R.D. and A.L. Goldin. 2000. Potentiation of rat brain sodium currents by PKA in Xenopus oocytes involves the I-II linker. Am. J. Physiol. Cell Physiol. 278:C638-C645.

Goldin, A.L.. 1999. Diversity of mammalian voltage-gated sodium channels, in Molecular and Functional Diversity of Ion Channels and Receptors. Annals of the New York Academy of Sciences, Eds. Rudy, B. and Seeburg, P., 868:38-50.

Smith, M.R. and A.L. Goldin. 1999. A mutation that causes ataxia shifts the voltage-dependence of the scn8a sodium channel. NeuroReport 10:3027-3031.

Pugsley, M.K. and A.L. Goldin. 1999. Molecular Analysis of the Na+ channel blocking actions of the novel class I antiarrhythmic agent RSD 921. Br. J. Pharmacol. 127:9-18.

Smith, R.D. and A.L. Goldin. 1998. Functional analysis of the rat I sodium channel in Xenopus oocytes. J. Neurosci.18:811-820.

Pugsley, M.K .and A.L. Goldin. 1998. Effects of bisaramil, a novel class I antiarrhythmic agent, on heart, skeletal muscle and brain Na+ channels. Eur. J. Pharmacol. 342:93-104.

Smith, M.R, R.D. Smith, N.W. Plummer, M.H. Meisler and A.L. Goldin. 1998. Functional analysis of the mouse Scn8a sodium channel. J. Neurosci.18:6093-6102.

Shih, T.M. R.D Smith, L. Toro and A.L. Goldin. 1998. High-level expression and detection of ion channels in Xenopus oocytes. Methods in Enzymology, ed. Conn, P.M., 293:529-556.

Shih, T.M. and A.L. Goldin. 1997. Topology of the Shaker potassium channel probed with hydrophilic epitope insertions. J. Cell Biol. 136:1037-1045.

Cantrell, A.R., R.D. Smith, A.L. Goldin, T. Scheuer and W.A. Catterall. 1997. Dopaminergic modulation of sodium current in hippocampal neurons via cAMP-dependent phosphorylation of specific site(s) in the sodium channel a subunit. J. Neurosci. 17:7330-7338.

Smith, R.D. and A.L. Goldin. 1997. Phosphorylation at a single site in the rat brain sodium channel is necessary and sufficient for current reduction by PKA. J. Neurosci. 17:6086-6093.

Smith, M.R. and A.L. Goldin. 1997. Interaction between the sodium channel inactivation linker and domain III S4-S5. Biophys. J. 73:1885-1895.

Kontis, K.J. and A.L. Goldin. 1997. Sodium channel activation gating is altered by substitution of voltage sensor positive charges. J. Gen. Physiol. 110:391-401.

Kontis, K.J. and A.L. Goldin. 1997. Sodium channel inactivation is altered by substitution of voltage sensor positive charges. J. Gen. Physiol. 110:403-413.

Kohrman, D.C., M.R. Smith, A.L. Goldin, J. Harris and M.H. Meisler. 1996. A missense mutation in the sodium channel Scn8a is responsible for cerebellar ataxia in the mouse mutant jolting. J. Neurosci. 16:5993-5999.

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