Welcome to the lab website!
We are a lab studying Wnt signaling in the Microbiology and Molecular Genetics Department at UC Irvine. The goal of research in the Waterman laboratory is to understand how the Wnt signaling pathway regulates target genes through the actions of LEF/TCF transcription factors. Dysfunctional Wnt signals misregulate gene expression and cause cancer and most of our work on LEF/TCFs is within the context of the final step of this dysregulated pathway. LEF/TCF proteins bind to Wnt Response Elements in target genes and recruit ß-catenin for gene activation or repressors for gene silencing. We are located in the Chao Family Comprehensive Cancer Center.