Publications
Fox-Walsh,
K.L., & Hertel, K.J. (2009) Proc Natl Acad Sci U S A 106: 1766-1771. “Splice-site
pairing is an intrinsically high fidelity process”. PDF File
Kotlajich,
M.V., Crabb, T.L., & Hertel, K.J. (2009) MCB 29. 1072-1082.
“Spliceosome assembly pathways for different types of alternative splicing
converge during commitment to splice-site pairing in A-complex”. PDF File
Kotlajich M.V., & Hertel K.J.
(2008) Mol Cell,
32,162-164.
“Death by splicing: tumor suppressor RBM5 freezes splice-site pairing”. PDF File
Shepard P.J., & Hertel K.J. (2008) RNA,14, 1463-1469.
“Genome-wide analysis identifies conserved RNA secondary structures that
promote alternative splicing”. PDF FILE
Hertel K.J. (2008). J. Biol. Chem., 283, 1211-1215.
“Combinatorial control of exon recognition”. PDF
FILE
Podcast associated with
this review article (Jan 18, 2008)
Sciabica KS, Hertel KJ. (2006) Nucleic
Acids Res.,
34,
6612-6620. “The splicing regulators Tra and Tra2 are unusually potent
activators of pre-mRNA splicing”. PDF
File
Dou
Y., Fox-Walsh K.L., Baldi P.F. & Hertel K.J. (2006) RNA, 12, 2047-2056.
“Genomic splice-site analysis reveals frequent alternative splicing close to
the dominant splice site”. PDF FILE
Hicks
M.J., Yang C.-R., Kotlajich M.V. & Hertel K.J.
(2006) PloS Biology, 4: e147, 943-951. “Linking
Splicing to Pol II Transcription Stabilizes Pre-mRNAs and Influences Splicing
Patterns”. PDF FILE
Commentary
on Hicks et al. PDF FILE
Hicks
M.J., Lam B.J., & Hertel K.J. (2005) Methods, 37, 306-313. “Analyzing
mechanisms of alternative pre-mRNA splicing using in vitro splicing
assays”. PDF FILE
Madocsai C., Lim S.R., Geib T., Lam
B.J., & Hertel K.J. (2005) Molecular
Therapy,
12, 1013-1022. “Correction of
SMN2
pre-mRNA splicing by antisense U7 small nuclear RNAs”. PDF FILE
Fox-Walsh
K.L., Dou Y., Lam B.J., Hung S., Baldi P.F., & Hertel K.J. (2005) Proc. Natl. Acad. Sci. USA, 102, 16176-16181,
“The Architecture of Pre-mRNAs Affects Mechanisms of Splice-site pairing”. PDF FILE
Freund
M., Hicks M.J., Konermann C., Otte M., Hertel K.J., & Schaal H. (2005) Nucleic Acids Res. 33, 5112-5119,
“Extended base pair complementarity between U1 snRNA and the 5’ splice site
does not inhibit splicing in higher eukaryotes, but rather increases 5’ splice
site recognition”. PDF FILE
Graveley,
B.R. & Hertel K.J. (2005) Encyclopedia of the Human Genome, doi: 10.1038/npg.els.0005039ls, Nature Publishing Group. “The SR
Protein Family”. PDF FILE
Ibrahim
E.C., Schaal T.D., Hertel K.J., Reed R., & Maniatis T. (2005) Proc.
Natl. Acad. Sci. USA
102, 5002-5007. “Serine/arginine-rich protein-dependent suppression of exon
skipping by exonic splicing enhancers”. PDF FILE
Commentary
on Ibrahim et al. PDF FILE
Hertel,
K.J. & Graveley, B.R., (2005) TIBS, 30, 115-118 “RS domains
contact the pre-mRNA throughout spliceosome assembly”. PDF FILE
Lim
S.R., & Hertel, K.J. (2004) Mol. Cell 15, 477-483. “Commitment to
splice site pairing coincides with A complex formation”. PDF FILE
Lam,
B.L., Bakshi, A., Ekinci, F.Y., Webb, J., Graveley, B.R., & Hertel, K.J.
(2003) JBC
278, 22740-22747.“Enhancer dependent 5' splice site control of fruitless
pre-mRNA splicing”. PDF FILE
Lam
B.J. & Hertel K.J. (2002) RNA 8, 1233-1241. "A general role for
splicing enhancers in exon definition". PDF
FILE
Lim
S.R., Hertel, K.J., JBC, (2001) JBC 276, 45476-45483 "Modulation of
SMN pre-mRNA splicing by inhibition of alternative 3' splice site
pairing". pdf
file
Graveley,
B.R., Hertel, K.J., & Maniatis, T. (2001) RNA 7, 806-818.
"The role of U2AF35 and U2AF65 in enhancer-dependent
splicing". pdf
file
Hertel,
K.J., & Maniatis, T. (1999) Proc. Natl. Acad. Sci. USA 96, 2651-2655,
"Serine-arginine (SR)-rich splicing factors have an exon-independent
function in pre-mRNA splicing". pdf
file
Graveley,
B.R., Hertel, K.J., & Maniatis, T. (1999) Curr. Biology. 9, R6-7,
"SR proteins are ‘locators’ of the RNA splicing machinery". pdf file
Hertel,
K.J., Stage-Zimmermann, T.K., Ammons, G., & Uhlenbeck, O.C. (1998) Biochemistry 37, 16983-16988,
"Thermodymanic dissection of the substrate-ribozyme interaction in the
hammerhead ribozyme". pdf
file
Graveley,
B.R., Hertel, K.J., & Maniatis, T. (1998) EMBO 17, 6747-6756,
"A systematic analysis of the factors that determine the strength of
pre-mRNA splicing enhancers". pdf
file
Hertel,
K.J., & Maniatis, T. (1998) Mol. Cell 1, 449-455, "The Function
of Multisite Splicing Enhancers". pdf
file
Hertel,
K.J., Peracchi, A., Uhlenbeck, O.C., & Herschlag, D. (1997) Proc. Natl.
Acad. Sci. USA
94, 8497-8502, "Use of intrinsic binding energy for catalysis by an RNA
enzyme". pdf file
Hertel,
K.J., Lynch, K.W., & Maniatis, T. (1997) Curr. Opin. Cell. Biol. 9, 350-357,
"Common themes in the function of transcription and splicing
enhancers". pdf
file