University of California, Irvine
College of Medicine
Medical Immunology (Fall 2008)
Core Notes
TABLE OF CONTENTS ............................................................................................................................. 1
CHAPTER 1 INTRODUCTION ........................................................................................................ 4
CHAPTER 2 ANTIGEN/ANTIBODY INTERACTIONS .................................................................. 8
CHAPTER 3 ANTIBODY STRUCTURE I....................................................................................... 15
CHAPTER 4 ANTIBODY STRUCTURE II...................................................................................... 19
CHAPTER 5 COMPLEMENT.......................................................................................................... 29
CHAPTER 6 ANTIBODY GENETICS: ISOTYPES, ALLOTYPES, IDIOTYPES.......................... 40
CHAPTER 7 CELLULAR BASIS OF ANTIBODY DIVERSITY: CLONAL SELECTION............ 47
CHAPTER 8 GENETIC BASIS OF ANTIBODY DIVERSITY........................................................ 55
CHAPTER 9 IMMUNOGLOBULIN BIOSYNTHESIS................................................................... 62
CHAPTER 10 BLOOD GROUPS: ABO AND Rh............................................................................. 70
CHAPTER 11 CELL-MEDIATED IMMUNITY AND MHC............................................................. 76
CHAPTER 12 CELL INTERACTIONS IN CELL MEDIATED IMMUNITY.................................... 83
CHAPTER 13 T-CELL/B-CELL COOPERATION IN HUMORAL IMMUNITY............................. 96
CHAPTER 14 CELL SURFACE MARKERS OF T-CELLS, B-CELLS AND MACROPHAGES...102
CHAPTER 15 CELL INTERACTIONS IN HUMORAL RESPONSE:THE CARRIER EFFECT.....107
CHAPTER 16 LYMPHOID TISSUE STRUCTURE ........................................................................ 113
CHAPTER 17 ONTOGENY OF THE IMMUNE SYSTEM............................................................. 118
CHAPTER 18 IMMEDIATE HYPERSENSITIVITY: ALLERGY.....................................................124
CHAPTER 19 TOLERANCE............................................................................................................ 133
CHAPTER 20 AUTOIMMUNITY: BREAKDOWN OF SELF-TOLERANCE................................ 140
CHAPTER 21 IMMUNODEFICIENCY.......................................................................................... 144
CHAPTER 22 IMMUNIZATION..................................................................................................... 150
CHAPTER 23 TUMOR IMMUNOLOGY........................................................................................ 155
APPENDIX............................................................................................................................................... 161
GLOSSARY............................................................................................................................................. 184
INDEX...................................................................................................................................................... 196